Dr. Mesmer is selling his instructional DVD "How to Pick Up Girls Through Mind Control" on a late night television infomercial. He uses his pretty lab assistant Jackie as his guinea pig, mesmerizing her with an oversized swinging paper clip. Now without question or hesitation she fulfills his every perverse desire. She is felt up and stripped naked, then ordered to talk to her boyfriend on the phone while blowing Mesmer. That's just the beginning!

The Scarlet Juggernaut is the leader of the Jamboree of Invincible Super Mutant Girls, better known by their initials as: the J.I.S.M. Girls. Through the use of a high tech ring, her arch nemesis Dr. Steele turns her against the other members of the group. Her first victim is her faithful sidekick, the Rump Ranger.

Alexis is a shy college student interning at an international conglomerate. The CEO mesmerizes away her shyness, so she can better compete in the cut throat world of big business. The procedure works too well. All vestiges of her shy self disappear, as she transforms into a shameless slut.

Naive mid-western gal Gina, travels to Los Angeles to attend a conference of the Church of Latter Day Virgins. She makes the mistake of staying with a family friend and his roommate, who spy on her while she is in the shower. Determined to have sex with her, the boys convince Dr. Mesmer to make a house call. Mesmer induces her using her own swinging rosary, and she satisfies all three men, abandoning her pious ways.

Steve, the CEO of Steele Enterprises, has brought a pretty junior executive with him on an important business trip. Unbeknownst to her, the company's line of seemingly innocent household items, when activated, have a mesmeric power over women. Steve plans on using her as his guinea pig at a demonstration for buyers from all over the world. But first, he must test their effectiveness on her in her hotel room in different pairs of pantyhose.

Young, beautiful Alicia is married to a cranky, old man. She loves him like a Stepford wife until she comes across the DVD, "How to Pick Up Girls Through Mind Control," while dusting. She snaps out of her haze and swears revenge on Dr. Mesmer. But his bodyguard zaps her with a gizmo, and she's "mind-fucked" by the two men.

J.I.S.M. Girl, Lavarella, who shoots magma from her hands, arrives at the lair of the icy Dr. Kelvin. Extreme cold is Lavarella's only weakness, and the evil doctor freezes her body and brain. She obediently fulfills his perverse desires. Who knows? He might even shoot some hot magma of his own.

Daisy chats on webcam with a prospective date. He induces her by reciting mesmeric poetry. Then he orders her to change into a sexy pair of pantyhose and pleasure herself. He commands her to give him her address, so he can meet her in person. When he arrives, he tears out the crotch, and they consummate their new found relationship.